Board Thread:General Discussion/@comment-1313357-20131217200655/@comment-3153244-20140903134201

From what I've heard, 4/2 Snipers are not very effective against DDTs. MOAB-SHREDR can take out the first 1-2 DDTs, but you would need more support towers or abilities to take out the extra ones that come.

Ground Zero and Spike Storm are actually the best options I've seen so far. I don't have Temples unlocked yet, because I don't see Consecrated Grounds anywhere, but I don't think any other upgrades are effective enough to take on DDTs. Spiked Mines might do alright, but not as well.